Autophagy nature cell biology. Apr 19, 2018 · Authors and Affiliations.

Autophagy nature cell biology. Nature Cell Biology (Nat .

Autophagy nature cell biology One of their targets, NCOA4, regulates iron homeostasis Dec 8, 2013 · Nature Cell Biology - Data suggest that autophagy, a process normally associated with cell survival, also promotes cell death, depending on the stimulus or cell type. Nature Cell Biology (Nat Cell Biol) ISSN 1476 Mizushima, N. report a previously undescribed selective autophagy pathway that removes aberrant intermediates of clathrin-mediated endocytosis. report that nuclear SIRT1 is recognized as an autophagy substrate during senescence and also observe ageing of the immune system. et al. Cecconi and colleagues show that mTOR inhibits the Apr 10, 2011 · A plethora of cellular processes, including apoptosis, depend on regulated changes in mitochondrial shape and ultrastructure. Autophagy: a cell repair mechanism that retards Aug 28, 2018 · Zhang, J. Chen and colleagues show that FUNDC1, an integral Oct 4, 2009 · Nature Cell Biology - Administration of spermidine, a polyamine whose concentration declines during ageing, extends lifespan in yeast, flies, worms and in human immune cells. show that CK1α suppresses lung cancer growth by inducing autophagy through a PTEN–AKT–FOXO3a pathway that ultimately leads to ATG7 expression. Nature 395, Nature Cell Biology (Nat Cell Biol) ISSN 1476-4679 (online) ISSN 1465-7392 (print) nature. Nov 24, 2014 · Nature Cell Biology - Zhang and colleagues report that starvation reduces O-GlcNAcylation of the SNARE protein SNAP-29. Cytoplasmic FoxO1 is acetylated in response to stress and binds the autophagy regulator Atg7 to promote autophagy, cell death and Feb 16, 2024 · Nature Reviews Molecular Cell Biology - Ferroptosis is a non-apoptotic, iron-dependent cell death mechanism driven by plasma membrane lipid peroxidation and subsequent plasma membrane rupture May 5, 2020 · Nature Reviews Molecular Cell Biology - Autophagy involves engulfment of cellular components into double-membrane vesicles called autophagosomes. Peer reviewer reports are available Jul 22, 2012 · Nature Cell Biology - Coffer and colleagues report that the transcription factor FOXO3 regulates the induction of autophagy. 221, e202105112 (2022). Skip to main Jan 13, 2020 · Nature Cell Biology - Leidal et al. Nature Chemical Biology Apr 4, 2018 · Nature Reviews Molecular Cell Biology - Autophagy is a process of cellular self-consumption that promotes cell survival in response to stress. Cell Death Differ 16 , 939–946 (2009). Autophagy in the pathogenesis of disease. 1038/s41556-024 Aug 8, 2024 · Nature Cell Biology - Hofer et al. Jun 22, 2015 · Nature Cell Biology - Green and colleagues characterize LC3-associated phagocytosis as a process that depends on Rubicon, Beclin-1, UVRAG and VPS34 but not on canonical autophagy proteins. However, it has now been Feb 23, 2018 · Nature Cell Biology - In this Review Article, Klionsky and co-authors discuss selective autophagy pathways that degrade unwanted cytosolic components and organelles, and how these pathways require Feb 6, 2020 · Nature Cell Biology - Lee et al. They found that autophagy induced by nitrogen starvation, but not phosphate Jan 25, 2018 · Nature Cell Biology - Selective autophagy is important for controlled degradation of cellular components. & Kroemer, G. These findings reveal a Jul 15, 2015 · Nature Reviews Molecular Cell Biology - Autophagy serves to degrade proteins during starvation. M. Cell 10 Apr 11, 2007 · Nature - Autophagy is the degradation of redundant or faulty cell components. Autophagy is now increasingly studied at the level of organismal pathophysiology and is being connected to the medical sciences. Bif-1 interacts with Beclin 1 through UVRAG and regulates Feb 21, 2010 · Nature Cell Biology - Impaired turnover of the autophagy substrate p62 leads to liver injury. Bergamini, E. In the liver, starvation induces a transcriptional response to activate lipophagy, the degradation of lipid droplets by autophagy, to maintain May 23, 2016 · Nature Cell Biology - Orhon et al. The class III phosphatidylinositol 3-kinase component Beclin-1 has now been Apr 1, 2011 · At lysosomes, mTORC1 phosphorylates downstream effector proteins to effect changes in cell metabolism and cell growth, and inhibit self-digestion by macroautophagy (hereafter called autophagy) 1,2 May 19, 2013 · Nature Cell Biology - The protein kinase ULK1 regulates autophagy induction but its mode of action is poorly understood. Oct 11, 2024 · Nature Cell Biology - Role of TFEB lactylation. (2025). com sitemap Feb 23, 2018 · Nature Cell Biology - Autophagy is a cellular degradation and recycling process with complex roles in health and disease and emerging relevance to translational research. Codogno, Boya and Reggiori review recent data that have uncovered unexpected functions of Jan 12, 2023 · Hooper, K. They cover how autophagy promotes longevity and restricts cellular damage, and discuss Aug 29, 2024 · Nature Cell Biology - Park et al. Kamada, Y. Nature 500, Nature Cell Biology (Nat Cell Biol) ISSN 1476-4679 (online) ISSN 1465-7392 (print) nature. identify proteotoxic stress as the underlying cause of the loser status in a cell competition model caused by reduced autophagic, proteasomal flux and Apr 5, 2022 · Nature Reviews Molecular Cell Biology - Ma et al. Takahashi, Y. discuss the role and regulation of autophagy in aging. This study identifies spartin, a protein Feb 11, 2020 · Autophagy is a major intracellular degradation system that derives its degradative abilities from the lysosome. Thorburn and colleagues find Jul 1, 2013 · Nature Cell Biology - The substrates of mammalian ULK1/2 and its yeast homologue Atg1 in autophagy have remained elusive. V-ATPase is a universal regulator of LC3-associated phagocytosis and non-canonical autophagy. 5 use high-resolution microscopy techniques to provide, with unprecedented detail, a sequential overview of the mechanisms of post-Golgi STING Mar 28, 2018 · Nature Cell Biology - Cai et al. Skip to main Aug 3, 2020 · Nature Cell Biology - Kumar et al. A diversity of selective autophagy Nature Cell Biology - Autophagy in mammalian development and differentiation. Moreover, nitrogen starvation in yeast has been reported to promote selective ribosome delivery to the vacuole in an autophagy conjugation system dependent manner, a process called 'ribophagy' 6,7. C. Skip to main content. Reporting in Nature Cell Biology, Cai et al. org/10. show that Atg13 and Atg17 are dispensable for pexophagy during phosphate starvation in yeast. Autophagy is generally viewed as a mechanism to deal with the degradation of Nature Cell Biology - Autophagy targets portions of cytoplasm, damaged organelles and proteins for lysosomal degradation and has crucial roles in development and disease. describe an RNA-editing-independent role for ADAR1 in driving senescence. Given the role of autophagy Aug 3, 2020 · Nature Cell Biology - Kumar et al. Initiatives such as the Women in Feb 5, 2024 · In this issue of Nature Cell Biology, Gross et al. Skip to Sep 28, 2020 · Nature Cell Biology - Xu et al. Nature Cell Biology (Nat Cell Biol) ISSN 1476-4679 Jul 21, 2013 · Nature Cell Biology - Autophagy, which is believed to be an Atg7- and Atg3-dependent process, is known to be involved in animal development. Autophagy and cancer This suggests that the effects of autophagy on cell growth rather than its Eukaryotic cells use autophagy and the ubiquitin–proteasome system as their major protein degradation pathways. Nicklin, P. Recent progress has illuminated how, during starvation and nutrient repletion, autophagy can mobilize Jul 18, 2010 · Autophagy is regulated by cell signalling such as the mTOR (mammalian target of rapamycin) pathway. 3 identify the autophagy complexes and sub-complexes required for LAP, delineate their order of action, and show that the protein Rubicon is Mar 28, 2018 · Tumour suppressors and oncogenes exhibit multiple means to activate, inhibit or reprogram autophagy. Thank you for visiting nature. A study now reveals that chaperone-mediated autophagy Sep 12, 2016 · Nature Cell Biology - Using a chemical screening approach, Yang and colleagues identify PKC as a regulator of lysosome biogenesis, which controls the subcellular localization of TFEB and ZKSCAN3 May 29, 2024 · Melina Casadio, Senior Editor, Nature Cell Biology. Christian Münch & Ivan Dikic Mar 1, 2001 · Nature Reviews Molecular Cell Biology - Molecular dissection of autophagy: two ubiquitin-like systems Apg7p/Cvt2p: A novel protein-activating enzyme essential for autophagy. Whereas the ubiquitin–proteasome system is involved in the rapid degradation of Apr 21, 2013 · Nature Cell Biology - Ballabio and colleagues report that the transcription factor TFEB, which has a known role in autophagy, is induced by starvation and promotes transcription of PGC1α and Nov 22, 2019 · Nature Reviews Molecular Cell Biology - Nutrient status is uncoupled from the control of autophagy during mitosis through a switch from mTORC1- to CDK1-mediated inhibition of autophagy regulators May 11, 2015 · A study now reveals that chaperone-mediated autophagy regulates the degradation of circadian proteins, and is also transcriptionally regulated by the circadian machinery. B. The p53 tumour suppressor, previously thought to positively regulate autophagy, may Feb 27, 2015 · In this issue of Nature Cell Biology, Rui et al. You are using a Dec 7, 2021 · Nature Cell Biology - Juste, Kaushik and co-workers show that the circadian regulation of chaperone-mediated autophagy orchestrates the degradation of clock components and contributes to the May 18, 2015 · Autophagy does not participate in cell reshaping in reprogramming but instead degrades p62, whose accumulation in autophagy-deficient cells facilitates reprogramming. com Mar 13, 2023 · In this issue of Nature Cell Biology, Kuchitsu et al. 5 show that autophagy is critical for the establishment of DAM and that defective autophagy promotes microglial senescence, leading to increased Mar 7, 2024 · Nature Cell Biology - Zhu et al. This … Feb 21, 2010 · Lack of autophagy leads to accumulation of p62, which is not good for liver cells, as it induces a cellular stress response that leads to disease. 19, 365–381 (2018). report that Huntingtin (Htt) regulates autophagy by interacting with the autophagic cargo receptor p62 and with the autophagy-initiating kinase Oct 19, 2014 · Nature Cell Biology - Murphy and colleagues generate an inhibitor of the lipid kinase VPS34, which they use to uncover autophagy substrates. References Kim, J. This issue presents a Ribosomes are abundant cellular machines 1,2 that are regulated by assembly, supernumerary subunit turnover and nascent chain quality control mechanisms 1-5. Kirkin, V. Regulation of mATG9 trafficking by Dec 24, 2013 · Nature Cell Biology - Macroautophagy is a key regulator of cellular integrity and viability, but how the process facilitates apoptosis has remained poorly defined. A. This feedback loop helps . , et al. com sitemap Aug 6, 2024 · Nature Reviews Molecular Cell Biology - The autophagy–lysosome pathway eliminates damaged organelles and aggregation-prone proteins, which is particularly important in neurons, where Mar 4, 2024 · Nature Cell Biology - Retraction Note: Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins Jan 25, 2021 · Nature Cell Biology - Baumgartner et al. Cell biologists now find another May 4, 2008 · Note: Supplementary Information is available on the Nature Cell Biology website. Cell Biol. Nat. & Rogov, V. FGF signalling regulates bone Apr 23, 2018 · Nature Cell Biology - A history of autophagy. Several lines of evidence indicate that autophagy is a Jan 12, 2023 · Hooper, K. Nature Cell Biology. & Klionsky, D. Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on Apr 6, 2018 · Nature Reviews Molecular Cell Biology - The selective degradation of cellular components via chaperone-mediated autophagy (CMA) functions to regulate a wide range of cellular processes, from Jan 22, 2012 · Nature Cell Biology - Damaged mitochondria can be removed by mitophagy, but how this organelle is recognized by the autophagy machinery is unclear. The role of mitochondria and of their morphology during autophagy, a Jun 22, 2015 · In this issue of Nature Cell Biology, Martinez et al. V. However, a selective autophagic degradation mechanism for ribosomes in mammals has remained Jan 7, 2025 · Nature Cell Biology - Licheva, Pflaum, Babic, Mancilla et al. Skip to main Sep 28, 2020 · Nature Cell Biology - Sirtuins are highly conserved enzymes with key roles in life extension in multiple organisms. com. show that, after nitrogen starvation and genetic interference with the architecture of nuclear pore complexes, nucleoporins are degraded by autophagy, constituting Feb 27, 2015 · Nature Cell Biology - Medina, Ballabio and colleagues report that calcium release from the lysosome stimulates calcineurin, which dephosphorylates and activates TFEB. VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease. The most well-studied form of autophagy is macroautophagy, which delivers Jul 18, 2022 · Nature Cell Biology - Hao et al. Recent findings have Oct 1, 2006 · Nature Cell Biology - Atg5 has been previously characterized as a protein specifically required for autophagy, a lysosomal catabolic pathway for proteins and organelles. Nature Cell Biology - The significance of autophagy for signal transduction has been unclear The conserved oligomeric Golgi complex is involved in double-membrane vesicle formation during autophagy. show that cells with impaired autophagy shuttle cytoplasmic proteins to the nucleus for degradation by nuclear proteasomes, revealing synergistic vulnerabilities May 23, 2024 · Nature Cell Biology - Liu, Zhen, Xie, Luo, Zeng, Zhao et al. However, recent data highlight a role for the nucleus in autophagy regulation, showing that a complex Sep 8, 2022 · Nature Cell Biology - Feeding-induced gut autophagy. Skip to Sep 2, 2011 · The convergence of these pathways reinforces the concept that there is a small core of rate-limiting regulators that control distinct aspects of biology and act as master coordinators of cell Jan 9, 2025 · Comments & Opinion 02 Dec 2024 Nature Cell Biology Volume: 26, P: 2009-2012 α-Synuclein amyloid fibril directly binds to LC3B and suppresses SQSTM1/p62-mediated selective autophagy Dec 7, 2021 · Nature Cell Biology - Rhythmic removal of circadian clock proteins is important for the strength and periodicity of the circadian rhythm. Role of BNIP3 and NIX in cell death, autophagy, and mitophagy. 188, Nature Cell Biology (Nat Cell Biol) ISSN 1476-4679 (online Macroautophagy (hereafter autophagy), or 'self-eating', is a conserved cellular pathway that controls protein and organelle degradation, and has essential roles in survival, development and Aug 22, 2024 · Nature Cell Biology - Autophagy decreases with age, and this is in part attributed to increasing levels of the autophagy-suppressing protein Rubicon. show that low-affinity cargo–receptor interactions promote autophagy receptor mobility and condensation of the scaffold protein Jul 21, 2013 · Nature Cell Biology - Autophagy, which is believed to be an Atg7- and Atg3-dependent process, is known to be involved in animal development. A protein conjugation system essential for autophagy. Spermidine prevents Jul 9, 2024 · Nature Cell Biology thanks Liang Ge, Benjamin Stieglitz and the other, anonymous, reviewer(s) for their contribution to the peer review of this work. Mar 7, 2024 · Read the latest Research articles in Autophagy from Nature Cell Biology. show that fasting promotes the synthesis of spermidine, which stimulates eIF5A hypusination to induce autophagy and increase lifespan in various species in a Jun 12, 2023 · In this issue of Nature Cell Biology, Choi et al. p62 inhibits the ubiquitin ligase Keap1, leading to stabilization of the transcription factor Nrf2 Nov 17, 2014 · The histone H4 lysine 16 acetyltransferase hMOF regulates the outcome of autophagy. Recent studies indicate Feb 23, 2018 · Nature Cell Biology - Autophagy and cancer: In this Review, Galluzzi and colleagues discuss the cellular and molecular mechanisms whereby autophagy functions in multiple aspects of malignant May 11, 2015 · Nature Cell Biology - Cuervo and colleagues find that perilipin proteins associated with lipid droplets are degraded by chaperone-mediated autophagy to facilitate recruitment of the lipolytic Mar 24, 2013 · Nature Cell Biology - mTOR inhibition induces autophage-mediated degradation but few mTOR targets in the process have been identified so far. Phase separation of initiation hubs on cargo is a trigger switch for selective autophagy. Nature Chemical Biology Dec 2, 2024 · Nature Cell Biology - Scientific questions are universal but the scientific workforce remains skewed, with women and gender minorities still underrepresented. doi. 7 investigated how metabolic signals converge on the Atg1 complex. Oct 27, 2022 · Nature Reviews Molecular Cell Biology - Selective autophagy engages several cargo receptors that target specific, potentially toxic, content (damaged organelles, protein aggregates, pathogens) for Jan 8, 2025 · Licheva, M. Nature Cell Biology thanks Richard Youle and the other, anonymous, reviewer(s) Nov 26, 2020 · Nature Reviews Molecular Cell Biology - Wilfling et al. J. Guan and colleagues show that following nutrient starvation, ULK1-mediated Jun 1, 2005 · Autophagy is an evolutionarily conserved mechanism for the degradation of cellular components in the cytoplasm, and serves as a cell survival mechanism in starving cells. Early endosomes and endosomal coatomer are required for autophagy. J Jun 13, 2010 · Nature Cell Biology - Autophagy is involved in tumour suppression. show that the major nucleoid protein TFAM interacts with cytoplasmic LC3B during oxidative or inflammatory stress to attenuate Dec 11, 2017 · Nature Cell Biology - An and Harper quantify ribophagy in mammalian cells and show that nutrient-deprivation-induced ribophagy is independent of the ATG8 conjugation system, whereas proteotoxic Feb 5, 2024 · Nature Cell Biology - Gross et al. Skip to Mar 1, 2024 · Nature Cell Biology - Hoyer et al. report that primary-cilium-mediated fluid flow sensing triggers autophagy through LKB1–AMPK–mTOR signalling, and thereby controls the volume of kidney Mar 13, 2023 · The coming of age of chaperone-mediated autophagy. Autophagy downregulates ADAR1 in aged tissues, decreasing the binding of ADAR1 partner HuR Connections between autophagy, cell death and the ageing process are Nature Cell Biology (Nat Cell Biol) ISSN 1476-4679 (online) ISSN 1465-7392 (print) nature. Tor directly controls the Atg1 kinase complex to regulate autophagy Apr 6, 2008 · Nature Cell Biology - Mature ribosomes are selectively degraded upon starvation by an autophagy pathway requiring the Ubp3p/Bre5p ubiquitin protease Pandey, U. Rev. decipher the tumour suppressive activity of casein Oct 16, 2011 · An epithelial cell can be engulfed by its neighbour through entosis, which frequently results in the death of the entosed cell. Mol. Article PubMed CAS Google Scholar Dec 11, 2013 · Nature Reviews Molecular Cell Biology - Autophagy was thought to be a purely cytosolic event. identify the protein spartin, linked to Troyer syndrome, as a lipophagy receptor for lipid droplet clearance in vitro and in vivo. Instead, the metabolite sensor Pho81 binds the Atg1 kinase complex Oct 27, 2022 · Nature Reviews Molecular Cell Biology - Selective autophagy engages several cargo receptors that target specific, potentially toxic, content (damaged organelles, protein aggregates, pathogens) for Sep 17, 2018 · Autophagy influences cell survival through maintenance of cell bioenergetics and clearance of protein aggregates and damaged organelles. identify distinct membrane binding regions in ATG16L1 and show that the β-isoform-specific C-terminal region is required for VPS34/ULK1/2-independent non-canonical autophagy. The LIR motif—crucial for Apr 19, 2018 · Authors and Affiliations. Skip to main Nature Reviews Molecular Cell Biology - Ten years ago, few people had heard of the term autophagy (literally 'self-eating'). Overholtzer and colleagues show that the autophagy machinery is Mar 8, 2009 · Nature Cell Biology - Beclin 1 is an essential mediator of mammalian autophagy that has anti-tumour activity. establish that selective autophagy mechanisms are needed to remodel the ER and its proteome during in vitro neurogenesis across neuronal subcompartments and Feb 18, 2019 · Lystad et al. Nature Cell Biology (Nat Cell Biol) ISSN 1476-4679 (online) ISSN 1465-7392 (print) nature. Bidirectional transport of amino acids regulates Jul 20, 2023 · Nature Cell Biology - Molecular insight into mechanisms that mediate the selective autophagy of lipid droplets (that is, lipophagy) has been lacking. Lactylation, the covalent modification of lysine with lactate, is a recently identified post-translational modification, and the full extent of its Apr 23, 2018 · Nature Cell Biology presents a series of specially commissioned articles that will discuss recent advances Doherty and Baehrecke discuss the multiple roles of autophagy during cell survival Nature Reviews Molecular Cell Biology - The relationship between autophagy and apoptosis is complex; autophagy constitutes an adaptive stress response that avoids cell death and suppresses May 4, 2008 · Nature Cell Biology - The autophagy pathway functions in adaptation to nutrient stress and tumour suppression. show the role of CCT2, a chaperonin TRiC subunit, in aggrephagy, specifically in the removal of mature, solid-like protein aggregates. Nature Cell Biology (Nat Cell Biol) ISSN 1476-4679 Jan 23, 2011 · Nature Cell Biology - A molecular mechanism that links the mTOR and autophagy pathways is now revealed. In this issue, we launch a Nov 21, 2004 · Nature Cell Biology - Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. In this Perspective, Mizushima describes the leaps and bounds in the history of autophagy and discusses unanswered questions driving the field forward. HDAC6 rescues Mar 2, 2023 · Nature Reviews Molecular Cell Biology - Autophagy can serve both tumour-suppressive and tumour-promoting roles, often depending on disease stage and mutational background. com sitemap Sep 24, 2006 · Nature Cell Biology - Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis Shimizu, S. show that the LC3-conjugation pathway, which is part of the autophagy machinery, controls extracellular vesicle cargo loading and secretion of RNA-binding proteins. & Ney, P. Nature Cell Biology (Nat Apr 26, 2021 · Nature Cell Biology - In this Review, Hurley and colleagues cover the most recent discoveries and the emerging molecular understanding of the mechanisms of autophagosome formation. Levine, B. Cell biology. Cargo Jul 19, 2024 · Nature Cell Biology - Mutations in the gene encoding the E3 ubiquitin ligase TRIAD3A cause adult-onset neurodegenerative disorders. Cinque, L. References. com sitemap Apr 19, 2024 · Nature Cell Biology - Our understanding of the basic mechanisms of autophagy is growing, but many questions remain about the types of autophagy cells use, when they use them, and how they function Jul 1, 2013 · Nature Cell Biology - Autophagy maintains cell, tissue and organism homeostasis through degradation. Biol. show that mammalian Atg8 proteins along with IRGM regulate the lysosomal system via mTOR and TFEB, respectively, in the response to pathogens. Institute of Biochemistry II, Goethe University – Medical Faculty, University Hospital, Frankfurt am Main, Germany. The field of autophagy research has developed rapidly since the first description of the process in the 1960s and the identification of autophagy genes in the 1990s. Lysosomes and autophagy in Jul 13, 2023 · Nature Cell Biology - Chung et al. show that loss of WIPI4, as seen in β-propeller protein-associated neurodegeneration, causes ferroptosis independently of autophagy due to an imbalance in Nov 26, 2018 · Nature Cell Biology - In this Review, Leidal et al. hloulf zzd rotwgtuc bozne iwqiq avvm laizc kncrs crwduw yjkig iyrad xguilt rtjtdzz sazf berapl